Recent research progress of the nucleotide-binding oligomerization domain-like receptor immune response to Mycobacterium tuberculosis infection

doi:10.3969/j.issn.1000-6621.2017.12.017

Abstract

Abstract: Mycobacterium tuberculosis (MTB) is the main pathogenic bacteria of Tuberculosis (TB). The immune responses of the host play an important role in the process of tuberculosis pathogenesis, which mainly work dependent on pattern recognition receptors (PPRs). Nucleotide-binding oligomerization domain-like receptor (NLR) is one of the important PPRs, which plays a vital role in the infection and pathogenesis of MTB. More than 20 types of NLR have been discovered hitherto. NLR primarily responses to intracellular bacteria and viruses, as well as the products released or degraded from these microorganisms. NLR functions in the process of recognition and elimination of pathogens by innate immune system in the early infection of MTB, as well as initiating adaptive immune response, secreting cytokines and inducing inflammation and autophagy. In recent years, the study of NLR has got new progress. In this paper, the immune response to MTB infection mediated by NLR and its relationship with the TB pathogenesis were analyzed comprehensively, so as to provide new clues for the study of interaction between MTB and host cells.

Key words: Receptors, pattern recognition, Receptors, proteinase-activated, Mycobacterium tuberculosis, Infection, Immunity

ZHANG Yu-qing, ZHANG Xu-xia, LIU Yi, LI Chuan-you. Recent research progress of the nucleotide-binding oligomerization domain-like receptor immune response to Mycobacterium tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2017, 39(12): 1343-1347. doi: 10.3969/j.issn.1000-6621.2017.12.017

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